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These water molecules are absent from the structure of the Meisenheimer complex bound to GST, implicating that deprotonation of the cysteine occurs during formation of the ternary complex which involves expulsion of the inner bound water molecule

Research by Zeng et al

Teft WA, Morse BL, Leake BF, et al

Cultured human RPE cells have been shown to synthesize and release IGF-1, suggesting that the RPE may serve as a source of IPM-IGF-1 in vivo [36]